Here's my favorite setup. I have found, after trying out most bag versions over the years, that there is no perfect setup. It's not even fair to try. The best we can hope for is a bag that helps us feel some relief as we manage a portfolio of tradeoffs around what we want and what we need. it helps if it has some style to it, at least for professional work that requires moving in an out of a variety of offices and meetings over a week.
The best quality bags I've found are ThinkTank and Ona. Others are good, too, but even some of the really expensive bags out there have frustrating inserts, or stiffness in the bag, that makes them hard to work out of. For those who use their bags to transport their equipment from one table top to another, I think there is a larger selection of bags that check most of the boxes you need. But if you're going to be working out of a bag for longer stretches, there are just a lot fewer options where the tradeoffs don't become overwhelming pretty fast.
I don't carry around a bunch of loose lenses. I almost never change them when shooting out of a walking bag, and I've found that the best way to get the benefit of multiple lenses is by keeping them mounted on multiple bodies. For all my professional work, I use two XT2 bodies (XT1 before that) and then I have a "third body" for a third lens, or that I use in terrible weather (never want to chance it with the main bodies if I can avoid it). My third body, right now, is an XT1 that also serves as a very small "cocktail camera" when I need it to be as unintrusive as possible.
I keep the 23mm on a body almost always, and then either the 56mm or the 90mm fuji lenses on the other. If it's during the day, I generally have the 90mm on it as it's a great tradeoff for size against the 135mm equivalent reach. I found I'd be called in to shoot a protest or a fire scene or etc, and I'd want to keep some distance. With fires, you never know the fumes present in the smoke. The three fuji bodies don't get too heavy for me, but I could never do this when I had the big DSLR rig going.
My daily carry setup is one of two Ona bags. I have the Bowery in canvas (leather does start to get too heavy with that bag) for days when I need all three bodies on me, plus a laptop or tablet. And when I only need one or two bodies and no computer, I use a leather bowery bag.
I find both bags to be outstanding in terms of both function and style. I can wear them with a tux or with jeans--in a boardroom or on a loading dock--and never have to think about it. All in all, I love this setup and it is, by far, the most productive set up I've worked with in my career. I can wear either of these bags, loaded with my equipment, all day long with only minor complaints about strain after even a long day of constant wear. I love the large pockets on the front of the ONA bags--they're among my favorite "front pockets" in the business. I only wish they had some sort of locking mechanism for slightly improved security when traveling.
Cell phone pics, but you get the idea.
Edited for spelling.