This is a very good point. The 33x44mm sensor in the GFX is much smaller than a 41x56mm 645 format film negative and yet most of the GF lenses have max apertures equal to traditional 645 system lenses. People who already own fast XF lenses and are thinking about "going to medium format" primarily to get more subject isolation should tread carefully because the change in DOF might not meet their expectations. For those that don't love to do math, here are the GF primes and what the equivalent X system lenses would be:
23mm f/4 = 12mm f/2
45mm f/2.8 = 23mm f/1.4
63mm f/2.8 = 33mm f/1.4
110mm f/2 = 57mm f/1.0
120mm f/4 = 62mm f/2
On the other hand, I use an X-E2 and a Mamiya 645 film camera with equivalent short telephotos. The DOF of the Mamiya 150mm f/3.5 and Voigtlander 56mm f/1.4 that use with the Fuji should be virtually identical on paper and yet the overall ability to separate the subject is not the same. The Mamiya lens has softer bokeh and film seems to be more tolerant of very contrasty and busy backgrounds (eg strongly lit vegetation), so I prefer it anytime there is enough light and the size and weight of the Mamiya is not an issue. The GFX lenses and sensor may likewise have many little differences relative to the X system that don't seem like much taken individually but add up to a meaningfully different whole.
In any case, I am happy Fuji made this camera. There are photographers who need (or want) higher resolution than APS-C can provide and I think going with 33x44 instead of FF was smart for both marketing and technical reasons.