I reply to myself, as - after searching and experimenting this and that during several days - I found today the reason to my problem... Should I tell that, as I haven't got any comments from you, the community? Ok, jokes apart. THE point is that the option Auto update custom settings under Image quality settings needs to be ENABLED! Well, as the manual is so obscure, not specific, with too short explanations and too general, I needed some 1-2 weeks (of course not day and night to find the solution. Anyway, now my X-T50's ISO setting holds, to that I set it.
By the way, the camera with the quality of the pictures, is great!!!! I love X-T50 after my reliable Nikon.
Well, one more thing, I would like this working: I transfer pictures to my Mac by using the app Photo transfer by wire because it is hazardous to take the memory card from the camera and put it to my MacBookPro because after Mac's reading the X-T50 doesn't recognise it any more!! Nothing but formatting the card *in my Nikon* helps, to get X-T50 to work with the card. So are there for this second issue any solutions??