Hi Bob123
I notice that this topic hasn't received much attention but is an issue which also affects my photography. Like you I wear glasses but I leave them on when I am shooting. Although I must say the the XT2 doesn't hamper me as much as my Nikon DSLR.
After reading your post I took out the camera and tried it with both eyes. I probably could use my right eye, but it doesn't seem natural after 50 years of shooting with the left. I agree that the nose, and glasses, do impede access to the full range of movement of the Q button, joystick, and menu system when shooting left-eyed. I have been primarily using the centre spot and then recomposing so I don't use the joystick much but I can see the difficulty in moving the focus point around. I use the four direction buttons on the back to activate certain functions such as AFC mode, White Balance, etc. (rather than the Q menu) and find the fingering very cramped trying to access those buttons while shooting left-eyed.
Another button I find awkward to use left-eyed is the AL button on the top right of the back.
For me, it would be helpful if the Q and menu buttons and the joystick were moved 1/2 inch to the right and the AL button brought down beside the Q button. I am not sure if that would negatively affect right-eyed shooters as I am sure a lot of ergonomic studies went into the current placement.
Let see if there are any other opinions.