At 16x20... maybe. It depends on the subject and how you use the lens. The F's lens is definitely at its weakest very close and wide-open. If you often shoot very close, the new lens could make a significant difference for you. If you like to use the lens wide-open, the new lens probably renders somewhat differently; sharper, but also with different bokeh and local contrast. Which you like better gets pretty subjective.
Personally, the only feature the V has that I really wish the F had was the ability to simultaneously record uncropped RAW when the digital teleconverter is in use. I just shoot twice to get around it, but it would be nice...
Whether those are "great advantages" is really up to you :).