As an experienced X-Pro user, I recently added an X-T1. The ability to customize was overwhelming.
The first thing I did was shut all the programmable buttons off. Then i would use the camera. As I needed an option more than a few times, I'd assign it to a button. As I went along, options that I accessed more often would be assigned to buttons that were easier to reach. With in a few days, I had all the options I used assigned to buttons.
And half my programmable buttons still have nothing assigned to them.