for me the beach-ball problem is solved:
I removed all the film simulation profiles from the ...\library\colorsync directory (I am on CO10 latest version)
put them in the app container as suggested by archidss, on 11 Jan 2017 - 8:03 PM (above here).
Also removed the extraneous spaces from the filenames, (left the numbers in place) and renamed the extension from icc to icm (so: FujiXPro2-1.Provia.icm)
restarted the computer, starting CO the first time took a bit longer. Profiles appeared in the recommend profile list and could be applied instantaneous, without any spinning beachball while using a large database (120k+ images, 180 GB)
after closing and restarting CO again I had a normal CO10 start-up time, profiles in the recommended list could be applied instantaneous without any spinning beachball.
Still in contact with Phase One on this.
Hans.