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It depends a bit on how long or wide you need the view angle to be and whether you still want to use the OVF or rely on the EVF. The 16-80 is a good lens but not especially great. In terms of image quality I'd prefer the 18-55 and pair it with a 14. That makes a great travel kit with only one filter size. If you don't mind a bit bigger, the 16-55/f2.8 is even slightly better than the 18-55 and it is weather resistant. If 16 is wide enough, you can forfeit on the 14 and get around with one lens. Fuji still has it's 18-135 which is relatively cheap as second-hand since the 16-80 arrived. It's not as good though and slower in aperture. In terms of image quality I'd rank the Fujinon standard zoom lenses as: 1. the 16-55/f2.8* 2. the 18-55/f2.8-4 3. the XC 15-50/f3.5-5.6 4. the 16-80/f4* 5. the 18-135/f3.5-5.6* 6. the XC 15-45/f3.5-5.6 The * marked will block a significant part of the OVF on an X-Pro3. Also bear in mind that the frame in the OVF gets really small above approx. 50mm. All lenses with variable aperture only have their fastest aperture at the widest point and quickly move to a slower aperture. The 18-55 e.g. is f2.8 at 18mm, but already f3.3 at 23mm and f4 at approx. 35mm (if memory serves me well). If you need a really longer solution than 80, the Tamron 18-300 was just introduced, but it's a bit of a big gun on an X-Pro3. Tamron has an excellent 17-70/f2.8 that seems perfect for APS-C, but we'll have to wait and see whether it will come for X-mount. Sigma is rumored to start offering X-mount lenses in 2022 and their recent 18-50/f2.8 is highly acclaimed for Sony E-mount APS-C, so hopefully that would be one of the first.

16-80 plus the 35 1.4…i add the 70-300 or the 50-230 (which is on sale since the 70-300 arrived) for my tele needs not on the x-pro3 but on the x-s10 if it makes any difference