I use LR for minimal adjustments and mostly for the digital asset management. I have over 250,000 images in LR right now. However, I use Capture One Pro for 95% of all my editing needs. My jpegs (from my GFX50r) are 40mb, and the TIFF's from raw are 310mb in size. My XT files are much smaller.
I have folders set up in LR (which are actually on my desktop) where I drop files into. Then I open C1Pro and sync that folder which I have set as a preset in C1Pro. Once I'm done processing in C1, I export into another folder called "Roundtrip from C1Pro which is also a default in C1pro and in LR. Back in LR, I then synch that folder and any jpegs and tiffs I generated are dropped in there. I can then move the finished images to the library for cataloging, keywording etc. Sounds complicated but I have it setup automatically and it works flawlessly for me.
Hope this helps.